aGEM that stands for “anatomic Gene Expresssion Mapping (aGEM)” is a development conceived to integrate phenotypic information from spatial and temporal distribution of expressed genes in mouse.

The aGEM Platform v1.2 is a powerful tool in the gene expression field that makes easy the access to information related to the anatomical pattern of gene expression in mouse, so that it can complement many functional genomics studies. The platform allows the integration of gene expression data with spatial-temporal anatomic data by means of an intuitive and user friendly display: http://bioweb.cnb.uam.es/VisualGenomics/aGEM.html.

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The aGEM Platform has been built extending the Distributed Annotation System (DAS) protocol that was originally designed to share genome annotations over the WWW. DAS is a client-server system in which a single client integrates information from multiple distributed servers.

The aGEM Platform provides information to answer three main questions (1) Which are the genes that are expressed in a given anatomical component?, (2) in which anatomical structures a given gene (or set of genes) is expressed?, and (3) is there any correlation among these findings?. Currently this Platform includes several well-known mouse gene expression resources such as EMAGE, GXD, and GENSAT together with several general biological information databases such as KEGG and OMIM. aGEM not only gives an integrated view of the five databases mentioned above, but also allows the experimentalist to retrieve relevant statistical information relating gene expression, anatomical structure (space) and developmental stage (time).